Basic Information
Name: Chlorogenic acid
EINECS: 206-325-6
CAS No.: 327-97-9
MDL: MFCD00003862
CAS Name: [1S-(1a, 3b, 4a, 5a)]-3-[[3-(3, 4-Dihydroxyphenyl)-1-oxo-2-propenyl] oxy]-1, 4, 5-trihydroxycyclohexanecarboxylic acid
Molecular formula: C16H18O9
Molecular weight: 354.31

Physical Property
The chlorogenic acid is a hemihydrate in the state of needle crystal (water); it turns into anhydrous compound under the temperature of 110 ℃; the melt point is 208 ℃; the water solubility in the 25 ℃ water is 4%, and the solubility is higher in hot water. It is very soluble in ethanol and acetone, slightly soluble in acetic acid ethyl, and insoluble in chloroform, ether, benzene and other lipophilic organic solvents.

Source
Chlorogenic acid is a commonly used plant extract mainly from Lonicera japonica Thumb, Lonicera hypoglauca Miq., Lonicera confusa DC, the dried buds, flowers or leaves of Lonicera dasytyla Rehd., the leaves of Eucommia ulmoides Oliv., the fruit of Crataegus oxyacantha Linn., as well as the seeds of Coffea arabica L, coffeacanephora Pierreex Froehn. and CoffealibericaBul1.exH1en.

Pharmacological Activity
1. Anti-bacteria, Anti-inflammation and Anti-virus
Chlorogenic acid is an important biologically active substance that has strong anti-bacterial and anti-inflammation capability. It can effectively restrain and kill a variety of pathogenic bacteria and has obvious curative effect on acute throat inflammation and skin diseases. The clinical use is for the treatment of acute bacterial infections. Also, having the function of resisting the virus that impairs the human immune system, chlorogenic acid can be used for the prevention and treatment of AIDS.

2. Anti-oxidation
This effective phenolic antioxidant contains a certain amount of R-OH radicals that can form hydrogen radicals having the function of anti-oxidation. The chlorogenic acid can help eliminate the activity of hydroxyl radicals, superoxide anion radicals and other radicals, so as to protect the human tissues from the damage caused by oxidation. Its antioxidant capacity is better than that of caffeic acid, p-hydroxyphenyl benzene acid, ferulic acid, syringic acid, butyl hydroxy anisole (BHA) and tocopherols.

3. Scavenging free radicals, Anti-aging, Anti-aging changes in the musculoskeletal system
Chlorogenic acid and its derivatives have stronger radical scavenging capacity than ascorbic acid, caffeic acid and tocopherol. In addition to effectively removing the DPPH radicals, hydroxyl radicals and superoxide anion radical, chlorogenic acid can also inhibit the oxidation of low-density lipoprotein. Apparently, this plant extract plays an important part in effectively scavenging of free radicals, maintaining the normal structure and function of body cells, preventing the mutations of tumor, slowing down aging and more.

4. Inhibiting tumor and mutation
Modern pharmacological experiments show that chlorogenic acid is a vital botanical extract that can prevent and inhibit tumor by reducing the use ratio of carcinogens and moving effectively in the liver. Capable of significantly inhibiting colorectal cancer, liver cancer and throat cancer, it is considered to be an effective chemical protectant against cancer.

5. Cardiovascular protection
As a proven free radical scavenger and antioxidant, chlorogenic acid is an excellent biologically active substance that can effectively protect the cardiovascular system.

6. Blood pressure reduction
Chlorogenic acid can help smoothly and steadily reduce blood pressure without causing any toxin or side effects.

7. Other functions
Having the specific inhibition effect on hyaluronic acid (HAase) and glucose-6-phosphatase (Gl-6-Pase), chlorogenic acid is well suited for wound healing, skin moisturizing, joint lubrication, suppression of inflammation as well as the regulation of blood glucose, etc. Studies have shown that oral administration of chlorogenic acid can significantly stimulate the secretion of bile, which can protect and benefit the gallbladder and liver; chlorogenic acid can also effectively inhibit the hemolysis of rat red blood cell caused by H2O2.

Applications
1. Food industry
(1) Natural chlorogenic acid can be used to produce health foods and beverages; this healthy pharmaceutical raw material can benefit gallbladder, resist bacteria and virus, stop bleeding, increase white blood cells, shorten the time of blood clotting and bleeding, excite the physiological function of the central nervous system.
(2) Chlorogenic acid is an excellent food additive that can enhance the aroma and protect the color of food and beverages. A small amount of chlorogenic acid can help stabilize the pigment.
(3) As a natural preservative agent, chlorogenic acid can be used to increase the stability of food and beverage and keep them fresh.
(4) Chlorogenic acid is a natural antioxidant that can perfectly take the place of synthetic antioxidant.

2. Healthcare industry
According to the pharmacopeia, chlorogenic acid is a common herbal extract with the functions of detoxification, anti-bacteria and anti-inflammation. Currently, it has become an important item for the quality control index of pharmaceutical preparations.

Healthcare products containing chlorogenic acid are endowed with the functions of clearing heat and detoxicating, skin rejuvenating and moisturizing, dispelling the excessive nicotine and alcohol, and so on.

3. Cosmetic industry
As a natural plant extract, chlorogenic acid and other natural polyphenols can not only excellently protect collagen against the damage of reactive oxygen and other free radicals, but also effectively prevent human skin from the harmful effects resulted from UV radiation. There have been a number of cosmetic products added with chlorogenic acid, such as the anti-urease cosmetic, sun/ UV protection cream, hair shampoo used for preventing the damage brought by hair dye, etc.

Safety
Data suggest that chlorogenic acid is almost non-toxic; the LD50 of immature rats receiving oral administration is more than 1g / kg; receiving intraperitoneal injection is more than 0.25g / kg.

Specification and Quality Control Index
We produce a variety of active natural products containing 2.0% to 99.0% chlorogenic acid; we are happy to produce chlorogenic acid products with customized specifications and quality control index.

Our quality control index includes trait, content, loss on drying, ash value, heavy metal limit, pesticide residue limit, microbial limit, etc.; other items of quality control index can be added based on customer needs.