Fmoc-Arg(pbf)-OH

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Fmoc-Arg(Pbf)-OH (CAS No. 154445-77-9) is an arginine derivative used in solid-phase peptide synthesis, featuring an Fmoc group on the N-terminus and a Pbf group protecting the guanidino side chain. This protection pattern helps prevent side reactions during chain assembly, making it suitable for sequences requiring high purity and selectivity. It is commonly used in the synthesis of GLP-1 analogs such as Semaglutide and Tirzepatide. The product is provided as a white solid, with a molecular weight of 648.8 g/mol and should be stored between –15 °C and –25 °C to maintain stability.

CAS No.: 154445-77-9
Molecular Formula: C₃₄H₄₀N₄O₇S
Purity: 99% min

Appearance White solid
Molecular Weight 648.8 g/mol
Density 1.4 ± 0.1 g/cm³ (predicted)
Boiling Point N/A
Melting Point 132 °C
Flash Point N/A
Packaging 25 kg / fibre drum
Customs Code 29359090
Storage Conditions Store at –15 °C to –25 °C in a sealed container. Protect from moisture and direct sunlight.

Product Name
1. Fmoc-Arg(Pbf)-OH;
2. Fmoc-L-arg(pbf)-OH;
3. (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid;
4. (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoic acid; Nalpha-Fmoc-Nomega-Pbf-L-arginine
Production Capacity 1 ton/month
Applications Raw material for GLP-1 peptides, polypeptides, Semaglutide, and Tirzepatide

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