Clean-In-Place (CIP) Systems for Bioprocessing
(Bioprocess CIP Skids)
The Clean-In-Place (CIP) system for bioprocessing is an essential configuration for biopharmaceutical equipment to comply with GMP requirements. Featuring simple operation, controlled cleaning procedures, and reliable cleaning performance, it is a standard auxiliary system for fermentation equipment.
The clean-in-place system enables efficient and reliable cleaning of bioreactors and process piping without equipment disassembly, significantly reducing labor intensity.
Cleaning performance can be quantitatively evaluated through conductivity measurement. Combined with computer-controlled automatic cleaning programs and conductivity feedback control, the cleaning system allows standardized and traceable management of cleaning effectiveness and efficiency.
- Alkali Tank, Acid Tank and Cleaning Tank
- Acid and Alkali Tanks: no jacket, no agitator;
- Cleaning Tank: no jacket, no agitator; steam heating with temperature control;
- Material: SUS316L
- CIP Supply Pump
- 1 Unit; In-line centrifugal pump;
- Material: SUS304 stainless steel
- CIP Return Pump
- 1 Unit; In-line centrifugal pump;
- Material: SUS304 stainless steel
- CIP Cleaning
- 100% coverage of all internal vessel surfaces; no dead zones; smooth surfaces with no residue
- Conductivity Monitoring System
- Online conductivity analyzer for concentration monitoring; automatic return control; pneumatic valves used
- CIP Interfaces
- Illuminated sight glass, hand hole, spray ball, temperature sensor, CIP return-line conductivity sensor
- Cleaning Modes
- Manual cleaning, automatic cleaning, and step-by-step cleaning; manual mode for commissioning and troubleshooting; automatic mode for routine operation
- Cleaning Procedure
- PLC-controlled valve sequencing to deliver cleaning solution and alkali solution; heating to set temperature; circulation cleaning through vessels and pipelines
- Time Control
- Customizable control of each cleaning step duration
- Temperature Control
- Online cleaning solution temperature control; measurement range: 0-90°C; control range: ambient to 90°C
- Control Cabinet
- Made of SUS304, thickness ≥1.5 mm; fireproof, moisture-proof, lightning-proof, waterproof, and dustproof; equipped with power sockets, lighting, and cooling fans
- Electrical Layout: Power and control circuits routed separately; sufficient spare capacity in cable trays or conduits
- Identification & Safety: All electrical components labeled; wires numbered at both ends; all terminals protected with insulating sleeves
- Power Wiring Standards: Three-phase power (380V A/C): yellow/green/red; neutral wire: blue; grounding wire: green-yellow